The Efficacy and Safety of Task-state-based Temporal Interference Stimulation (TI) in the Treatment of Patients With Depression

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Conditions studied: Major Depressive Disorder

In brief

This study intends to investigate the intervention efficacy of temporal interference stimulation (TI) on mood symptoms in depressed patients, as well as to explore the neuroimaging mechanisms of TI improvement in depressed patients using pre- and post-treatment magnetic resonance.

Key facts

Study ID

NCT06826469

Run by

First Affiliated Hospital of Zhejiang University

People needed

43

Starts

2026-06-01

Expected to finish

2027-06-01

Last updated by the study team

2026-05-27

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18-50 years old, right-handed, and completed nine years of compulsory education;
• Met Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria for depression;
• HAMD-17≥18;
• Subject was a first-time medication-naïve patient or had previously used antidepressant medication and was currently off medication for ≥2 weeks;
• The subject/ legal guardian is willing to actively cooperate with the treatment and sign an informed consent form after fully understanding the temporal interference stimulus (TI).

You may not qualify if…

• Co-morbid other psychiatric disorders, including bipolar disorder, affective psychiatric disorders, anxiety spectrum disorders, mental retardation, substance dependence (abuse), etc.;
• Severe suicidal ideation or behavior;
• History of a serious physical illness or a disease that may affect the central nervous system;
• Neurologic disorders or risk of seizures such as previous cranial disorders, head trauma, abnormal electroencephalograms, magnetic resonance evidence of structural brain abnormalities, or a family history of epilepsy;
• Contraindications to magnetic resonance scanning or time-interference stimulation (TI), such as the presence of metallic or electronic devices in the body (intracranial metallic foreign bodies, cochlear implants, pacemakers and stents, and other metallic foreign bodies);
• Those who have received or are receiving electroconvulsive therapy (ECT ), modified electroconvulsive therapy (MECT ), transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), or other neurostimulation treatments;
• Pregnant and lactating women, and women of childbearing age with positive urine pregnancy.

Where it is running

• Department of Psychiatry, First Affiliated Hospital of Zhejiang University — Hangzhou, Zhejiang, China

Full record on ClinicalTrials.gov

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