7T Anatomo-functional Characterization of Structures in the Action Observation Network
Recruiting now
Conditions studied: Brain Function, Cerebral Palsy
In brief
The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the AON circuit, using an ultra-high field (7T), high spatial resolution Magnetic Resonance Imaging protocol. The main questions it aims to answer are: * Can we demonstrate the involvement of subcortical areas and cerebellum in the AON circuit in each single-subject? * Can we obtain similar results in a small group of patients with Cerebral Palsy (CP), in order to demonstrate the feasibility of this approach for the study of the mechanisms of AON reorganization, after early brain damage? * Are different patterns of functional activation correlated to different clinical characteristics of CP patients? Participants will perform a 7 Tesla MRI scan, with a functional and anatomical dedicated protocol and will have a comprehensive clinical assessment before the MRI exam.
Key facts
- Study ID
- NCT06826287
- Run by
- IRCCS Fondazione Stella Maris
- People needed
- 40
- Starts
- 2024-12-02
- Expected to finish
- 2025-08-09
- Last updated by the study team
- 2025-02-13
Who can join
Age: 11 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients with pre-, peri- or post-natal brain injury, documented by a previous MRI examination of the brain;
- Intellectual development within the norm or within the mild deficit area, to guarantee understanding and cooperation in the 7T fMRI study;
- Understanding of the Italian language;
You may not qualify if…
- Contraindications to performing the 7T fMRI exam;
- Neuropsychiatric comorbidity that precludes collaboration in the 7T fMRI study;
- Lack of capacity to understand and to will;
- Pregnancy;
- For Healthy Controls
- Inclusion Criteria:
- Absence of known neurological and psychiatric pathologies;
- Understanding of the Italian language;
- Exclusion Criteria:
- Contraindications to performing the 7T fMRI exam;
- Neuropsychiatric comorbidity that precludes collaboration in the 7T fMRI study;
- Lack of capacity to understand and to will;
- Pregnancy;
Where it is running
- IRCCS Fondazione Stella Maris — Calambrone, Pisa, Italy (enrolling)
- Fondazione IMAGO7 — Calambrone, PISA, Italy
Full record on ClinicalTrials.gov
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