Pancrelipase With Nutritional Supplement in Patients at Risk of Malnutrition (EFFORT-ENZO)

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Malnutrition

In brief

This study investigates if pancreatic enzymes in combination with oral nutritional supplement can improve nutrient bioavailability in older people with malnutrition or at risk of malnutrition.

Key facts

Study ID

NCT06826105

Run by

Philipp Schuetz

People needed

20

Starts

2025-09-22

Expected to finish

2026-01-01

Last updated by the study team

2025-09-30

Who can join

Age: 70 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Informed Consent as documented by signature
• Male or female 70 years of age or older
• Hospitalized at site
• Nutrition Risk Screening 2002 (NRS-2002) ≥ 3
• eGFR ≥ 30 mL/min/1.73 m2 (EPI-CKD) based on medical history (no older than 6 months)
• Ability to eat orally

You may not qualify if…

• Patients with acute cardiovascular event ≤ 2 days
• Patients with terminal conditions
• Patients diagnosed with pancreatic exocrine insufficiency (EPI) treated with pancreatic enzyme replacement therapy (PERT)
• Patients having a planned transplant or new-onset dialysis in the next 6 months.
• Patients having a colectomy, resection of the small intestine or cholecystectomy
• Known hypersensitivity to any of the substances or excipients of the ONS or the medicinal product

Where it is running

• Kantonsspital Aarau — Aarau, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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