Sleep TMS for Depression

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Major Depression, Sleep

In brief

The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.

Key facts

Study ID

NCT06824415

Run by

Stanford University

People needed

55

Starts

2025-05-01

Expected to finish

2028-05-30

Last updated by the study team

2026-06-23

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults ages 18-65 years
• Current Major Depressive Disorder (MDD) diagnosis
• Failed ≥1 antidepressant medication
• Moderate-to-severe depression
• Stable antidepressant medication dose for ≥ 6 weeks prior to enrollment
• Healthy control participants are adults ages 18-65 years without current MDD symptoms, not taking antidepressant or antipsychotic medications, and without major psychiatric, neurological, substance use, medical conditions affecting brain function, or TMS/MRI contraindications.

You may not qualify if…

• Intellectual disability
• Significant head injury/neurological disorder
• Pregnancy or postpartum
• TMS/MRI contraindications
• Active substance use/suicidal ideation

Where it is running

• Stanford University — Stanford, California, United States (enrolling)

Full record on ClinicalTrials.gov

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