Gastric Feeding Versus Transpyloric Feeding in Infants with Severe Bronchopulmonary Dysplasia, a Crossover Study

Recruiting now · Not applicable

Conditions studied: Bronchopulmonary Dysplasia, Feeding Intolerance

In brief

Hospitalized infants with severe bronchopulmonary dysplasia (BPD) and feeding intolerance will be randomized to 2 weeks of continuous gastric feeding or continuous transpyoloric feeding. Subjects will crossover after 2 weeks and receive 4 weeks of each feeding mode. Respiratory status will be assessed to determine the optimal feeding mode for each infant.

Key facts

Study ID

NCT06821776

Run by

Le Bonheur Children's Hospital

People needed

25

Starts

2025-02-05

Expected to finish

2030-02-01

Last updated by the study team

2025-02-12

Who can join

Age: 0 and older, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients born <32 weeks' gestation
• Currently admitted to the Le Bonheur NICU
• Grad 2 or 3 BPD (positive pressure or intubated at 36 weeks PMA)
• Signs of gastroesophageal reflux, chronic aspiration, or other feeding intolerance.

You may not qualify if…

• Known gastrointestinal anomalies
• Unable to tolerate ≥100mL/kg/day enteral feeding
• Congenital anomalies likely to alter feeding techniques
• Surgical feeding tube in place or expected within the next 8 weeks
• Expected to remain hospitalized <8 weeks

Where it is running

• Le Bonheur Children's Hospital — Memphis, Tennessee, United States (enrolling)

Full record on ClinicalTrials.gov

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