Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History
Recruiting now · Phase 1
Conditions studied: Abortion, Habitual, Infertility Unexplained, Embryo Implantation, Pre-Eclampsia
In brief
The aim of this study is preliminary exploration of the effectiveness and duration of autologous decidual-like NK cells therapy in improving uterine NK cells dysfunction.
Key facts
- Study ID
- NCT06821685
- Run by
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
- People needed
- 14
- Starts
- 2025-02-13
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2025-11-17
Who can join
Age: 22 and older, up to 40. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- abnormal uterine NK cell function;
- have one of the following medical history: unexplained recurrent spontaneous abortions (≥2 spontaneous abortions, including biochemical pregnancy), repeated implantation failure (failure of implantation of good-quality embryos in at least two IVF cycles), unexplained infertility, early-onset severe gestational hypertension or early-onset fetal growth restriction;
- have clear fertility desires;
- normal ovarian function or with frozen embryos;
- edometrium thickness measured by vaginal ultrasound before ovulation or at mid-luteal phase >= 7mm;
- 18kg/m\^2 < Body mass index < 30kg/m\^2;
You may not qualify if…
- using progesterone receptor modulator;
- chromosomal karyotype abnormalities in one spouse;
- severe endometriosis, uterine fibroids affecting the shape of the uterine cavity or the size of the whole uterus more than 2 and a half months of pregnancy, uterine malformation, uterine adhesion or thin endometrium;
- uncontrolled autoimmune diseases;
- abnormal blood coagulation function, abnormal liver and kidney function, or other uncontrolled basic diseases (hypertension, diabetes, thyroid disease, etc.) that the researcher access which may affect the progress of the study;
- history of pelvic malignant tumors;
- currently participating in other clinical studies;
- allergic to blood products.
Where it is running
- The Affiliated Drum Tower Hospital of Nanjing University — Nanjing, Jiangsu, China (enrolling)
Full record on ClinicalTrials.gov
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