N-Care Project: Enhancing Asian-Pacific Collaboration
Recruiting now
Conditions studied: Whole Genome Sequencing, Genetic Disease, Critical Care, Intensive Care, Nanopore Sequencing
In brief
Through Asian-Pacific multinational collaboration, we aim to utilize third-generation genome sequencing to rapidly diagnose genetic diseases in critically ill infants and young children, achieving the goal of early diagnosis for targeted treatment.
Key facts
- Study ID
- NCT06821386
- Run by
- National Taiwan University Hospital
- People needed
- 70
- Starts
- 2025-02-17
- Expected to finish
- 2032-12-31
- Last updated by the study team
- 2025-02-20
Who can join
Age: any, up to 2. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age: infant/newborn less than 18 months
- Admitted to intensive care unit
- At least one of the following conditions A. Specific anomaly highly suggestive of a genetic etiology
- Multiple birth defects
- Single major malformation that required intervention (surgery or medication)
- Significantly abnormal EKG
- Significant hypotonia
- B. Children with high-risk stratification on assessment of a Brief Resolved Unexplained Event (BRUE) with any of the following:
- Recurrent severe infection events
- Recurrent or prolonged seizures
- Unexplained cardiopulmonary resuscitation (CPR)
- Suspect inborn error of metabolism
You may not qualify if…
- Infants with a definitive non-genetic diagnosis: ex as below A. An infection with normal response to therapy B. Isolated prematurity C. Transient hypoglycemia D. Isolated unconjugated hyperbilirubinemia E. Isolated Transient Neonatal Tachypnea F. Those where the clinical course can be explained without genetic testing
- Confirmed genetic diagnosis explains illness
- Lack of consent: Families who do not consent to genetic testing or data sharing.
- Infants without sufficient DNA sample quality/quantity: Where the quality or quantity of the DNA sample is inadequate for sequencing.
Where it is running
- National Taiwan University Hospital — Taipei, Taiwan (enrolling)
Full record on ClinicalTrials.gov
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