A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults

Recruiting now

Conditions studied: Healthy, Insulin Resistance

In brief

The objective of the study is to use neurological techniques to obtain quantitative measurements of nervous system control of skeletal muscle activity in adults aged 60-85 who are either long-term resistance exercisers or who are untrained.

Key facts

Study ID

NCT06820658

Run by

Mayo Clinic

People needed

80

Starts

2025-02-26

Expected to finish

2028-10-01

Last updated by the study team

2026-08-05

Who can join

Age: 60 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participant must have a BMI between 18.5 and 38
• Participant be aged between 60 and 85
• Regularly exercises at least 5 days a week a minimum of 30 minutes per day.
• Engages in less than 2 days of exercise less than 30 minutes each day.
• Participant must use the Mayo Clinic patient online portal.
• Participant must be able to understand English without the need of an interpreter.
• Must be willing to be contacted for research
• Participant must be willing and capable to provide consent.
• Participants shall be generally healthy as deemed acceptable by the principal investigator
• Men and women will be participant in this study. Women cannot be pregnant during this study.

You may not qualify if…

• Surgical History - Gastric surgery, pacemaker placement, weight loss surgery, metabolic and obstetric surgery.
• Smokers will be excluded from the study.
• Medications: Insulins, common diabetic drugs, anti-hyperglycemic drugs, beta blockers cardiac selective, beta-blockers noncardiac selective, oral steroids, opioids anti-depressants, and hormones
• Conidiations and Diagnosis: Disorder of coronary artery, hepatic failure, gastroparesis, disorder of the adrenal gland, drug related disorders, substance abuse, malignant neoplastic disease, psychotic disorders, disorder of skeletal muscle, finding of brain, chronic kidney disease, renal failure syndrome, disorder of pulmonary circulation, cerebrovascular disease, neuro developmental disorder, disorder of immune function, disorder of central nervous system.
• Participants are not to have an abnormal value as part of a lipid panel within the past 6 months.
• Participant will be excluded if they have recreational drug use or a history of alcohol abuse
• Inability or unwillingness of individual or legal guardian/representative to give written informed consent.
• Current or past participation within a specified timeframe in another clinical trial, as warranted by the administration of this intervention.
• Participant will be excluded if they have epilepsy.
• Participant will be excluded if they have cranial metal/device implants
• Participant will be excluded if they are pregnant

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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