Pilot Study to Characterize the Endometriosis Steroidome and Its Link to Endocrine Disruptors and Vaginal Dysbiosis

Recruiting now

Conditions studied: Endometriosis

In brief

Endometriosis is a systemic, steroid-dependent, inflammatory disease characterized by the growth of endometrial-like tissue outside the uterus, affecting approximately 10 % of women of childbearing age. The etiology and pathophysiology of endometriosis is not completely understood to support effective treatment and prevention strategies. Despite the steroid dependency, little is known concerning the underlying metabolism of estrogen and other tightly related steroids. Moreover, shortening the long diagnostic delays is a major priority in endometriosis research.

Key facts

Study ID: NCT06820450
Run by: Nantes University Hospital
People needed: 135
Starts: 2025-07-01
Expected to finish: 2027-07-01
Last updated by the study team: 2026-06-24

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Women aged 18 to 45
Free, informed and written consent from the patient to participate in the study
Good understanding of the French language
Patient affiliated to or benefiting from a social security or similar scheme
Specific inclusion criteria for each group:
Group 1. Controls.
Women with no laparoscopically confirmed signs suggestive of deep endometriosis.
No clinico-biological criteria in favour of a diagnosis of endometriotic disease, nor any radiological signs (ultrasound or MRI) suggestive of endometriosis.
Group 2. Cases of deep endometriosis.
Newly diagnosed women (less than 12 months).
Severe, deep endometriotic pathology with surgical indication (clinical examination, imaging tests, pre-operative findings).

You may not qualify if…

Intercurrent diagnosis of pregnancy.
Presence of other hormone-dependent pathologies (e.g. breast cancer, PCOS).
Acute infection.

Where it is running

CHU de Nantes — Nantes, France (enrolling)

Full record on ClinicalTrials.gov

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