Effect of Dexamethasone on Post-spinal Hypotension

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Post Spinal Anaesthesia Hypotension, Geriatric Population, Orthopedic Surgeries

In brief

The goal of this clinical trial is to learn if intravenous dexamethasone is effective for prevention of post spinal hypotension in geriatric population undergoing orthopedic surgeries. The main question aim to answer is: Does intravenous dexamethasone in participants undergoing orthopedic procedures of lower limb under spinal anesthesia prevents post spinal hypotension? Researchers are comparing two groups of participants * Participants in (Dexamethasone Group) Group D are receiving intravenous dexamethasone 8mg preoperatively * Participants in (Placebo Group) Group P are receiving placebo preoperatively.

Key facts

Study ID

NCT06819436

Run by

Shaheed Mohtarma Benazir Bhutto Institue of Trauma

People needed

170

Starts

2025-02-01

Expected to finish

2025-05-01

Last updated by the study team

2025-02-11

Who can join

Age: 65 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patient undergoing orthopedic surgery in spinal anesthesia. ASA ≤ 2.

You may not qualify if…

• Patients with history of cardiac arrhythmias. Patients with history of acute coronary syndrome. Patient with history of polytrauma. Patients with contraindication to SA (e.g., coagulopathy, thrombocytopenia, allergy to local anesthetic agent) and those on steroids or serotonin related medications (e.g., selective serotonin reuptake inhibitor) will be excluded.

Where it is running

• Shaheed Mohtarma Benazir Bhutto Institute of Trauma — Karachi, Sindh, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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