Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)
Recruiting now · Phase 3
Conditions studied: Ovarian Cancer
In brief
This clinical trial is designed to evaluate the efficacy and safety of T-DXd in combination with bevacizumab versus bevacizumab monotherapy as first-line maintenance therapy, in participants with human epidermal growth factor 2 (HER2)-expressing (immunohistochemistry \[IHC\] 3+/2+/1+) advanced high-grade epithelial ovarian cancer.
Key facts
- Study ID
- NCT06819007
- Run by
- Daiichi Sankyo
- People needed
- 582
- Starts
- 2025-03-19
- Expected to finish
- 2032-01-31
- Last updated by the study team
- 2026-07-02
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- Scripps Clinic — La Jolla, California, United States (enrolling)
- Palo Alto Medical Foundation — Palo Alto, California, United States (enrolling)
- Broward Health Medical Center — Fort Lauderdale, Florida, United States (enrolling)
- Jupiter Medical Center — Jupiter, Florida, United States (enrolling)
- Mount Sinai Medical Center — Miami Beach, Florida, United States (enrolling)
- AdventHealth Cancer Institute — Orlando, Florida, United States (enrolling)
- Woman's Care FL — St. Petersburg, Florida, United States (enrolling)
- Nancy N. & J.C Lewis Cancer & Research Pavillion- St. Josephs/ Candler Health System — Savannah, Georgia, United States (enrolling)
- Endeavor Health Evanston Kellogg Cancer Care Center — Evanston, Illinois, United States (enrolling)
- Indiana University — Indianapolis, Indiana, United States (enrolling)
- Trials365 LLC — Shreveport, Louisiana, United States (enrolling)
- Greater Baltimore Medical Center — Towson, Maryland, United States (enrolling)
- Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States (enrolling)
- Trinity Health St. Joseph Mercy Ann Arbor — Ann Arbor, Michigan, United States (enrolling)
- Corewell Health — Grand Rapids, Michigan, United States (enrolling)
- Minnesota Oncology Hematology PA — Minneapolis, Minnesota, United States (enrolling)
- St. Vincent Gynecologic Oncology — Billings, Montana, United States (enrolling)
- Valley Health System — Paramus, New Jersey, United States (enrolling)
- Laura and Isaac Perlmutter Cancer Center at NYU Langone — New York, New York, United States (enrolling)
- Icahn School of Medicine at Mount Sinai — New York, New York, United States (enrolling)
- Columbia University — New York, New York, United States (enrolling)
- UNC Hospital — Chapel Hill, North Carolina, United States (enrolling)
- Miami Valley Hospital South — Centerville, Ohio, United States (enrolling)
- Disney Family Cancer Center — Burbank, California, United States (enrolling)
Full record on ClinicalTrials.gov
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