A Study of the Effect of Multiple Doses of Diltiazem on the Plasma Levels of MK-6916 in Healthy Participants (MK-6916-005)

Completed · Phase 1

Conditions studied: Healthy

In brief

The goal of the study is to learn what happens to levels of MK-6916 in a healthy person's body over time. Researchers will compare what happens to MK-6916 in the body when it is given with or without another medicine called diltiazem.

Key facts

Study ID

NCT06818968

Run by

Merck Sharp & Dohme LLC

People needed

37

Starts

2025-02-27

Expected to finish

2025-08-08

Last updated by the study team

2025-08-26

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The key inclusion criteria include but are not limited to the following:
• Has a body-mass index (BMI) 18 to 32 kg/m\^2

You may not qualify if…

• The key exclusion criteria include but are not limited to the following:
• Has a history of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological abnormalities or diseases
• Has a history of cancer (malignancy)
• Has a history of cardiac arrhythmia or recurrent unexplained syncopal events
• Has a first-degree relative with multiple unexplained syncopal events, unexplained cardiac arrest or sudden cardiac death, or has a known family history of an inherited arrhythmia syndrome
• Has positive test(s) for hepatitis B surface antigen, hepatitis C antibodies, or human immunodeficiency virus

Where it is running

• Fortrea CRU, Madison ( Site 0001) — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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