CRF2 Agonist for the Treatment of Worsening Heart Failure

Paused · Phase 2 · Has a placebo group

Conditions studied: Worsening Heart Failure

In brief

This study assesses the effects of the investigational drug COR-1167 in subjects hospitalised due to worsening of heart failure (HF)

Key facts

Study ID

NCT06815471

Run by

Corteria Pharmaceuticals

People needed

300

Starts

2025-08-07

Expected to finish

2026-12-01

Last updated by the study team

2026-07-22

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed written informed consent
• Heart failure hospitalization (HFH) during previous 12 months
• Prescribed an oral loop diuretic for at least 1 month preceding the index event
• NT-proBNP ≥1,000 pg/mL or BNP ≥250 pg/mL
• Requires treatment with i.v. diuretics for volume overload
• At least 1 risk factor for diuretic resistance
• Admitted to the hospital not more than 48 hours prior to randomization

You may not qualify if…

• Index event primarily triggered by an acute event (e.g. AMI, PE, arrhythmia)
• Requirement for i.v. inotropic therapy or i.v. vasodilators, mechanical ventilation, high-flow oxygen therapy, or NIV
• Requirement for, or planned use of LVADs, IABP, or any type of MCS
• History of solid organ transplant or active on a transplant list
• SBP <100 mmHg
• eGFR < 20 mL/min/1.73 m2
• CABG, PCI, implantation of CRT, heart valve procedure or any cardiac surgery within 1 month prior to screening or planned during the study
• Severe stenotic cardiac valvular disease
• Severe chronic pulmonary disease requiring chronic steroid therapy or chronic oxygen therapy (> 2 L/min)
• Uncorrected severe hyperthyroidism or hypothyroidism
• Severe restrictive, obstructive, or infiltrative cardiomyopathy
• Body weight < 70 kg
• Use of any investigational drug(s) within 5 half-lives of screening
• At high risk of death (defined as life expectancy ≤1 year) from causes other than heart failure or any disease that, in the opinion of the Investigator, will preclude their safe participation in this study, and will make implementation of the protocol or interpretation of the study results difficult
• Presence of any other conditions (e.g. geographic, social) actual or anticipated, that the Investigator feels would restrict or limit the subject's participation or compliance with all study procedures Subject is the Investigator or any Subinvestigator, research assistant, pharmacist, study coordinator, other staff or relative thereof directly involved in the conduct of the study

Where it is running

• Wayne State University - Detroit Receiving Hospital — Detroit, Michigan, United States
• Wayne State University - Sinai Grace Hospital — Detroit, Michigan, United States
• Cone Health Moses Cone Hospital — Greensboro, North Carolina, United States
• NC Heart and Vascular Research, LLC — Raleigh, North Carolina, United States
• Ohio State University — Columbus, Ohio, United States
• South Oklahoma Heart Research, LLC — Oklahoma City, Oklahoma, United States
• Fakultní nemocnice Brno — Brno, Czechia
• Sdružené zdravotnické zařízení Krnov — Krnov, Czechia
• Fakultní nemocnice Ostrava — Ostrava, Czechia
• Nemocnice Slaný — Slaný, Czechia
• Aleksandre Aladashvili Clinic LLC — Tbilisi, Georgia
• LTD "Israeli-Georgian Medical Research Clinic Healthycore" — Tbilisi, Georgia
• Acad. G. Chapidze Emergency Cardiology Center LTD, Department of Internal Medicine and Medical Research — Tbilisi, Georgia
• Acad. G.Chapidze Emergency Cardiology Center, LTD, Department of Multi-center Clinical Trials — Tbilisi, Georgia
• Bokhua Memorial Cardiovascular Center LTD — Tbilisi, Georgia
• St. Michael's Hospital LLC — Tbilisi, Georgia
• Tbilisi Heart and Vascular Clinic, LTD — Tbilisi, Georgia
• Georgian Dutch Hospital — Tbilisi, Georgia
• LTD Tbilisi Heart Center — Tbilisi, Georgia
• Semmelweis Egyetem, Általános Orvostudományi Kar, Városmajori Szív- és Érgyógyászati Klinika — Budapest, Hungary
• Budapesti Uzsoki Utcai Kórház, Kardiológia Osztály — Budapest, Hungary
• Pécsi Tudományegyetem, Klinikai Központ, I. sz. Belgyógyászati Klinika — Pécs, Hungary
• Szegedi Tudományegyetem, Általános Orvostudományi Kar, Családorvosi Intézet — Szeged, Hungary
• Zala Vármegyei Szent Rafael Kórház, Kardiológiai Osztály — Zalaegerszeg, Hungary
• Indiana University Health Methodist Hospital — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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