Study of the Immunological Infiltrate and Immunometabolic Immunometabolic Profile of Patients with Acute Leukaemia
Recruiting now
Conditions studied: Acute Leukemia
In brief
LThe main aim of this project is to provide an immunophenotypic and immunometabolic characterisation of patients with Acute Leukaemia, before and after therapy, and to understand how changes in the immune system impact the response to therapy. Specifically: 1. The association between the molecular and metabolic characteristics of leukaemic cells and those of the surrounding immune system will be assessed, in order to identify immune-modulatory metabolic mechanisms activated by malignant cells. 2. The association between immunometabolic signatures and response to therapies will be assessed. 3. The role of EVs as a vehicle for metabolic units capable of regulating the metabolism of immune system cells will be explored.
Key facts
- Study ID
- NCT06814444
- Run by
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- People needed
- 170
- Starts
- 2023-11-11
- Expected to finish
- 2030-12-11
- Last updated by the study team
- 2025-02-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- PATIENT
- Diagnosis of Acute Leukaemia.
- Eligibility for a treatment scheme involving either conventional chemotherapy or innovative therapies, such as monoclonal antibodies, molecular therapies with specific targets, metabolic and immunological therapies.
- age ≥ 18 years.
- Signature of informed consent by patients at the time of diagnosis.
- Healthy donors (AIL BOLOGNA ODV volunteers)
- age ≥ 18 years.
- Signature of informed consent.
You may not qualify if…
- no one
Where it is running
- IRCCS Azienda Ospedaliero-Universitaria di Bologna — Bologna, Bologna, Italy (enrolling)
Full record on ClinicalTrials.gov
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