Project neuroARTEMIS

Recruiting now · Not applicable

Conditions studied: Stimulant Use, Human Immunodeficiency Virus (HIV), Depression

In brief

The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave. By learning more about how these processes work, the hope is to be able to develop better treatments to help with problems like depression and substance use. This study is intended for individuals that are HIV positive, currently taking prescription antiretroviral medications, and use stimulants. Through this intervention, the aim is to determine if this positive affect intervention can lead to reductions in stimulant use and depressed mood.

Key facts

Study ID

NCT06814275

Run by

Wake Forest University Health Sciences

People needed

189

Starts

2025-04-29

Expected to finish

2028-12-31

Last updated by the study team

2025-09-11

Who can join

Age: 18 and older, up to 59. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-59 years old
• Weekly use of stimulants reported in the past month or a score of 4 or more on the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST)
• Confirmed HIV diagnosis
• Current receipt of daily oral antiretroviral therapy (ART) medication
• English fluency/literacy

You may not qualify if…

• Acute brain infection (e.g., neurosyphilis, toxoplasmosis)
• Acutely symptomatic bipolar I or psychotic disorder
• Prescription for immunomodulatory medications or other immunotherapy
• Any MRI contraindications
• If applicable, on antidepressant medication regimen for at least 2 months

Where it is running

• Wake Forest University School of Medicine — Winston-Salem, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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