Variable-thread Versus Standard Dental Implants for Replacing Missing Teeth
Recruiting now · Not applicable
Conditions studied: Dental Implants
In brief
Background and objectives: Primary and secondary implant stability remain the most relevant and reliable clinical indicator for long-term survival of dental implants. Hence modifications of surface characteristics and implant macro-designs were introduced over the last two decades to enhance osseointegration during the initial phase of healing. In this context, a variable-thread self-cutting implant design was recently introduced to improve primary stability. At present, there are limited number of studies that evaluated this variable-thread implant design. These studies were mostly experimental, of short duration and limited number of participants. Therefore, the aim of the present randomized controlled trial is to compare two implant designs (variable-thread versus standard) in terms of clinical, radiographic and patient-reported outcomes. Methods: A total of 24 participants, who require replacement of a posterior single tooth with dental implant, will be randomly allocated to two equal sized groups. In the test group, the participants will receive variable-thread implants, while standard implants will be placed to replace missing teeth in the control group. In addition to evaluating implant stability, the trial will also report on clinical and radiographic implant outcomes at various time points.
Key facts
- Study ID
- NCT06808854
- Run by
- Mohammed Bin Rashid University of Medicine and Health Sciences
- People needed
- 24
- Starts
- 2025-08-01
- Expected to finish
- 2027-11-01
- Last updated by the study team
- 2025-07-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Aged more than 18 years.
- Good general health (ASA I or II, according to the American Academy of Anesthesiology).
- Require replacement of a posterior single missing tooth with a dental implant.
- Controlled oral hygiene (full-mouth plaque and bleeding scores ≤ 25% at baseline.
- Good compliance and commitment to attend follow-up review appointments.
- Willing to provide informed consent. Exclusion criteria
- A healing period of less than four months postextraction at implant site.
- Localized/generalized periodontitis.
- Bone metabolic disease and/or taking medications that affect bone metabolism.
- Long term use of non-steroidal anti-inflammatory medications.
- History of malignancy, radiotherapy or chemotherapy.
- Pregnant or lactating women.
- Severe bruxism or parafunctional habits.
- Large occlusal discrepancies.
- Smokers.
Where it is running
- MBRU — Dubai, United Arab Emirates (enrolling)
Full record on ClinicalTrials.gov
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