Abnormal Connectivity Involving the Social Reciprocity Network in Autism and the Impact of Neurostimulation in Mitigating the Abnormalities
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Autism Spectrum Disorder
In brief
There is no consensus regarding the neurological substrate underpinning ASD. The investigators describe the novel concept of "social reciprocity network" and hypothesize that aberrant connectivity/oscillatory patterns affecting this network contribute to the core deficits in ASD. The overarching goal of this trial is to explore abnormalities involving the neuronal connectivity and oscillatory patterns within the social reciprocity network and to elucidate the role of modulating this network via rTMS in improving the above measures and social cognition in ASD. Quantitative electroencephalography (QEEG) coherence and spectral power analysis are reliable measures of neuronal connectivity and dynamics. The investigators aim to study the QEEG coherence/spectral power analysis to explore the neuronal dynamics affecting the social reciprocity network in ASD.
Key facts
- Study ID
- NCT06807684
- Run by
- Christiana Care Health Services
- People needed
- 12
- Starts
- 2024-08-15
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2025-02-21
Who can join
Age: 13 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Fulfilling the DSM-V criteria for ASD and confirmed by CARS2, HF Exclusion criteria
- Patients with ASD exhibiting significant anxiety or contact avoidance, precluding them from cooperating with the procedure
- Patients with a known diagnosis of seizures
- Presence of any metallic implants or devices in the head or neck area
- Pregnant women
Where it is running
- Christiana Care — Newark, Delaware, United States (enrolling)
Full record on ClinicalTrials.gov
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