Can Blood Biomarkers of Inflammation and BDNF be Used to Assess the Effectiveness of Collagen Mesotherapy in Chronic CMPS?

Enrolling by invitation

Conditions studied: Myofascial Pain Syndrome - Neck, Spondyloarthrosis, Neck Pain, Cervical Pain

In brief

The aim of the study is to assess the concentration of anti-inflammatory markers after the use of cervical spine mesotherapy in the course of pain syndrome. The study is randomized. Patients will be divided into two groups: A - mesotherapy using injectable type I collagen, B - mesotherapy using 1% lignocaine. The mesotherapy procedure will be performed five times, at weekly intervals. Blood will be collected before the start of mesotherapy, a week after its completion and after 3 months of follow-up. In addition, the effectiveness and safety of mesotherapy of the cervical spine will be assessed.

Key facts

Study ID

NCT06807177

Run by

National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland

People needed

40

Starts

2025-01-08

Expected to finish

2026-01-12

Last updated by the study team

2026-01-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients with chronic (>12 weeks) cervical spine pain syndrome of muscular, myofascial nature without radiation to the upper limb
• recent MRI or CT scan of the cervical spine (up to 6 months)
• no serious diseases: cancer, rheumatology, metabolic
• no allergy to lignocaine 1% or injectable type I collagen

You may not qualify if…

• another cause of cervical spine pain
• lack of patient consent

Where it is running

• National Institute of Geriatric, Rheumatology and Rehabilitation — Warsaw, Poland

Full record on ClinicalTrials.gov

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