Reducing Blood Culture Contamination With the Use of a Needle-less Blood Draw Device (The PIVO Trial)

Recruiting now · Not applicable

Conditions studied: Blood Culture Contamination, Infection

In brief

Blood cultures (BCs) are a blood test to look for an infection. Two problems with the sample collection are contamination by germs outside of the blood and not collecting enough blood in the tube, resulting in unusable samples. Many patients requiring a BC also have a peripheral intravenous catheter ("catheter") but these are not normally used for blood sampling. This means that patients receive many painful needles for both catheter insertion and blood sampling. There is a needle-free blood collection device (PIVO Pro) which can be used with a catheter to collect a blood sample. The goal of the PIVO Trial is to see if using the PIVO Pro for blood culture sample collection will have a lower amount of contamination than the usual method of blood sample collection. Patients 18 and older at 3 emergency departments will be included. Research nurses will look for patients in emergency who need a blood culture sample taken and they will be asked if they want to be involved in the trial. Half of the participants will use the PIVO Pro to take their blood sample and half will have the usual way of collecting blood. Participants do not have to do anything specifically for the trial. Information about the blood collection and results of the blood culture will be collected from the medical records and recorded for the trial.

Key facts

Study ID

NCT06806709

Run by

The University of Queensland

People needed

1148

Starts

2025-08-18

Expected to finish

2026-12-31

Last updated by the study team

2026-02-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Blood culture requested due to suspected bloodstream infection
• Patients receiving a 22 gauge short peripheral intravenous catheter (or larger)

You may not qualify if…

• Patients who have already commenced intravenous antimicrobial medications in the emergency department

Where it is running

• Caboolture Hospital — Caboolture, Queensland, Australia (enrolling)
• Redcliffe Hospital — Redcliffe, Queensland, Australia (enrolling)
• Robina Hospital — Robina, Queensland, Australia (enrolling)
• The Gold Coast University Hospital — Southport, Queensland, Australia (enrolling)

Full record on ClinicalTrials.gov

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