Predictive Analytics and Clinical Decision Support to Improve PrEP Prescribing

Running, not enrolling · Not applicable

Conditions studied: HIV

In brief

Scale-up of HIV preexposure prophylaxis (PrEP) is a key strategy of the U.S. initiative to end the HIV epidemic, but healthcare providers lack tools to support PrEP discussions and prescribing for patients likely to benefit. This research will evaluate whether integrating automated tools into electronic health records to help providers efficiently and equitably identify potential candidates for PrEP, discuss PrEP, and prescribe PrEP can improve PrEP initiation and persistence in safety-net community health centers. It will achieve this by conducting a stepped-wedge trial of a decision support tool with an embedded HIV prediction model to identify patients likely to benefit from PrEP. The intervention will be delivered to healthcare providers in 16 community health centers within the national OCHIN network.

Key facts

Study ID

NCT06805877

Run by

Harvard Pilgrim Health Care

People needed

16

Starts

2025-04-21

Expected to finish

2030-07-01

Last updated by the study team

2025-04-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Delivery site saw at least 500 distinct patients in 2024 during in-person or telehealth visits
• Delivery site had at least 10 new HIV diagnoses or positive HIV screening tests in 2023
• Delivery site provides primary care other than pediatrics, and the primary care department(s) were active on OCHIN Epic as of 1/1/2023

You may not qualify if…

• Delivery site specializing in HIV or STI care
• Correctional facilities
• Mobile sites
• School-based health center sites

Where it is running

• Bay Area Community Health Liberty Clinic — Fremont, California, United States
• Lifelong East Oakland Health Center — Oakland, California, United States
• TrueCare Oceanside Family Medicine — Oceanside, California, United States
• DAP Legacy — Palm Springs, California, United States
• One Community Health Midtown Campus — Sacramento, California, United States
• Southwest Community Health Center 968 Fairfield Avenue — Bridgeport, Connecticut, United States
• Mercy Care Decatur Street — Atlanta, Georgia, United States
• Siouxland Community Health Center Sioux City — Sioux City, Iowa, United States
• Lynn Community Health Center 269 Union — Lynn, Massachusetts, United States
• Mattapan Community Health Center Blue Hill — Mattapan, Massachusetts, United States
• Neighborhood Family Practice Ridge Community Health Center — Cleveland, Ohio, United States
• Signature Health Painesville — Painesville, Ohio, United States
• Variety Care Sequoyah — Oklahoma City, Oklahoma, United States
• Prism Belmont — Portland, Oregon, United States
• Bee Busy Wellness Center Bray Oaks — Houston, Texas, United States
• Seattle Roots Community Health Carolyn Downs Community Clinic — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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