Early Feeding Versus Delayed Feeding After Colorectal Endoscopic Submucosal Dissection

Recruiting now · Not applicable

Conditions studied: Endoscopic Submucosal Dissection, Colorectal Neoplasms

In brief

Currently, there are no clear guidelines regarding the optimal timing for dietary restart after gastrointestinal endoscopic submucosal dissection (ESD). While several studies have addressed upper gastrointestinal ESD, a meta-analysis reported that early feeding, initiated within one day after the procedure, showed no statistically significant difference in complication rates compared to delayed feeding initiated after two or more days. Moreover, early feeding was associated with shorter hospital stays and higher patient satisfaction. However, to the best of our knowledge, no studies have investigated early feeding in colorectal ESD. On the other hand, in the context of surgical procedures involving the gastrointestinal tract, several studies suggest that early feeding may offer clinical advantages over delayed feeding. The aim of this study is to explore the optimal timing for dietary restart following colorectal ESD. In the early feeding group (\<24 hours), patients begin water intake if no abnormalities are observed during a follow-up examination conducted two hours post-procedure. If no further issues arise after an additional two hours, a liquid diet is initiated. In contrast, the delayed feeding group (\>24 hours) maintains fasting on the day of the procedure and begins a liquid diet the following day. The study will compare the early and delayed feeding groups in terms of early post-procedural adverse events (occurring within 24 hours after the procedure)(e.g., bleeding, perforation, post-coagulation syndrome), patient satisfaction, and delayed post-procedural adverse events (occurring more than 24 hours after the procedure).

Key facts

Study ID

NCT06805123

Run by

Pusan National University Hospital

People needed

204

Starts

2025-02-01

Expected to finish

2026-12-30

Last updated by the study team

2026-06-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Under 18 years of age
• Patients with unresolved colorectal cancer
• Patients with non-remissive inflammatory bowel disease (IBD)
• Patients with blood coagulation disorders
• Patients with a prothrombin time (PT) INR ≥ 1.5 despite medical correction
• Pregnant patients
• Patients who refuse to participate in this study

Where it is running

• Inje university busan paik hospital — Busan, South Korea (enrolling)
• Pusan National University Hospital — Busan, South Korea (enrolling)
• Kosin university gospel hospital — Busan, South Korea (enrolling)
• Ulsan university hospital — Ulsan, South Korea (enrolling)
• Pusan National University Yangsan Hospital — Yangsan, South Korea (enrolling)

Full record on ClinicalTrials.gov

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