Interest of Sperm Insemination at 42 Hours Post hCG Compared to 36h in Intrauterine Insemination
Recruiting now · Not applicable
Conditions studied: Infertility, Intrauterine Insemination (IUI)
In brief
Intrauterine insemination (IUI) is a common therapeutic option to treate infertility. Typically performed 36 hours post-hCG injection to trigger ovulation. However, research suggests delaying IUI to 42 hours post-hCG may improve egg quality and sperm synchronization for fertilization, leading to higher pregnancy rates. A proposed superiority study aims to compare IUI timing at 36 hours versus 42 hours post-hCG injection to evaluate its impact on live birth rates. The primary objective is to assess the effectiveness (live birth rates) of IUI at two different post-hCG timing intervals (42-43 hours vs 36-37 hours).
Key facts
- Study ID
- NCT06804538
- Run by
- University Hospital, Toulouse
- People needed
- 692
- Starts
- 2025-09-09
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2026-05-05
Who can join
Age: 18 and older, up to 43. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Single unmarried woman or heterosexual or homosexual couple in which the woman wishing to carry the pregnancy is aged 18 to 43 and the spouse is aged 18 to 60 at the time of inclusion
- 2 permeable tubes for the woman receiving the insemination
- Spouse's sperm (Number of inseminable sperm ≥ 1 million in prior survival migration test) or sperm donation
- 1st or 2nd intrauterine insemination for this child project
- Ovarian stimulation by gonadotropin with GnRH antagonist (introduced on a fixed day or according to the follicular size criterion of the center)
- Luteal phase support with a progestin until at least the pregnancy test
- Affiliation or beneficiary of a social security scheme or equivalent for both partners of the couple if applicable
- Free and informed consent signed by the unmarried woman or both members of the couple
- Couples and unmarried women meeting the conditions for access to PMA according to the French bioethics law
You may not qualify if…
- Endometriosis stage III or IV
- History of ectopic pregnancy
- ≥ 3 spontaneous miscarriages
- Single woman or couple where one of the two partners (or both) is (are) under the protection of justice, under guardianship or under curatorship
- Single woman or couple who have already participated in the study once
- Single woman or couple participating in another interventional clinical study
Where it is running
- CHU Toulouse — Toulouse, France (enrolling)
- CHU Bordeaux — Bordeaux, France
- CHU La Réunion — La Réunion, France
- CHU Poitiers — Poitiers, France
Full record on ClinicalTrials.gov
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