The Effect of Cycling, Running, and Playing Rugby on Three Biomarkers That May Indicate Brain Injury

Completed · Not applicable

Conditions studied: Healthy Male and Female Subjects

In brief

The goal of this clinical trial was to determine if and how the biomarkers neurofilament light (NfL), brain lipid binding protein (BLBP), and amyloid precursor protein (APP) accumulated over 72 hours in venous blood following running, cycling, or playing rugby as compared to a non-exercising control group. Participants in this study were recreationally active and healthy males and females 18 - 49 years of age. The main questions it aimed to answer was: Do NfL, BLBP, and APP increase following exercise? Researchers compared the accumulation of NfL, BLBP, and NfL among runners, cyclists, rugby players, controls, and between sexes in each category. Participants were asked to either run, bike, play a rugby match, or abstain from exercise. In the exercising group, blood was drawn from a vein prior to the activity, immediately after the activity, 30 minutes after the activity, 1 hour after the activity, 24 hours after the activity, 48 hours after the activity, and 72 hours after the activity. In the non-exercising group blood was drawn from a vein one time.

Key facts

Study ID

NCT06804291

Run by

Appalachian State University

People needed

32

Starts

2021-10-16

Expected to finish

2022-02-15

Last updated by the study team

2025-02-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Apparently Healthy
• Those in the running group must be able to run 6.44 kilometers
• Those in the cycling group must be able to cycle 39 kilometers
• Those in the ruby group must be members of the university club rugby team

You may not qualify if…

• Individuals with diabetes
• Individuals with heart disease
• Individuals who are pregnant
• Individuals who get light-headed or dizzy while donating blood

Where it is running

• Appalachian State University — Boone, North Carolina, United States

Full record on ClinicalTrials.gov

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