RTMS for Refractory Auditory Hallucinations Based on Personalized Targets Using Magnetoencephalography
Recruiting now · Not applicable
Conditions studied: Refractory Auditory Hallucinations, Schizophrenia
In brief
This study is an before-after study in the same patient, which enrolled 36 psychiatric patients with refractory auditory hallucinations. The target of patient intervention relies on the results of magnetoencephalography localization. The medication and dosage remain unchanged during the intervention period. The investigators assume that the intervention targets for each auditory hallucination patient are individualized.
Key facts
- Study ID
- NCT06802939
- Run by
- Shanghai Mental Health Center
- People needed
- 36
- Starts
- 2025-02-05
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2025-02-14
Who can join
Age: 13 and older, up to 55. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Clinical diagnosis of schizophrenia
- Must be able to right-handed
- Primary school education or above
- Understand and sign a written informed consent form (jointly signed by the guardian and the participant if under 18 years old)
- Existence of persistent auditory hallucinations (defined as: taking sufficient antipsychotic medication for at least 6 months, combined with 3 antipsychotic medications still ineffective, and no significant improvement in auditory hallucinations symptoms, with an AHRS score still>12)
You may not qualify if…
- MECT treatment within the past 3 months
- Major physical illnesses (organic lesions such as sensory and motor disorders, neurological disorders, and traumatic brain injury)
- Taboo symptoms for rTMS treatment (such as intracranial metal implants)
- Aggressive behavior and an impulse to damage equipment
- Metal (including orthodontic treatment, dental implants) and tattoos inside the body
- Claustrophobia
Where it is running
- Shanghai Mental Health Center — Shanghai, China (enrolling)
Full record on ClinicalTrials.gov
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