Posaconazole Plus PD-1 Inhibitors and Chemotherapy vs PD-1 Inhibitors and Chemotherapy in Neoadjuvant Therapy for Triple Negative Breast Cancer
Recruiting now · Phase 2
Conditions studied: Breast Cancer
In brief
Triple-negative breast cancer (TNBC) is as sociated with shorter overall survival than other breast cancer subtypes, despite the use of curative-intent anthracycline- and taxane-based systemic chemotherapy. Neoadjuvant therapy is now also recognized as the standard treatment for patients with high-risk TNBC. The Keynote-522 study demonstrated that the application of pembrolizumab has raised the pathological Complete Response (pCR) rate in TNBC to over 60%, but nearly 40% of patients still do not achieve pCR. How to further improve the pCR rate in TNBC patients has become a hot topic of current research. Posaconazole is an antibiotic used to prevent invasive Aspergillus and Candida infections and to treat oropharyngeal candidiasis. Our preclinical studies have found that posaconazole can inhibit immune cell-mediated steroidogenesis to restrict TNBC tumor progression. The investigators design and begin a a prospective randomized controlled clinical study to explore the effectiveness of posaconazole in the neoadjuvant treatment of TNBC.
Key facts
- Study ID
- NCT06802757
- Run by
- Shandong Cancer Hospital and Institute
- People needed
- 72
- Starts
- 2025-05-01
- Expected to finish
- 2028-02-01
- Last updated by the study team
- 2026-02-25
Who can join
Age: 18 and older, up to 70. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Female, aged ≥ 18 and ≤ 70 years old;
- first-confirmed TNBC;
- cT1cN1-3M0 or cT2-4N0-3M0;
- ECOG score 0-1 points.
You may not qualify if…
- Stage I or IV;
- History of previous breast cancer;
- Patients with a history of other tumors who have received systemic therapy or local radiotherapy;
- No immune system disease or connective tissue disease;
- No history of hormone therapy;
- Pregnant/lactating.
Where it is running
- Breast Cancer Center Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences — Jinan, Shandong, China (enrolling)
Full record on ClinicalTrials.gov
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