Rehabilitation Methods for Unilateral Spatial Neglect in Stroke Patients

Recruiting now · Not applicable

Conditions studied: Unilateral Spatial Neglect (USN)

In brief

Stroke remains one of the leading causes of mortality and disability worldwide. Between 30% and 40% of patients who have had an acute cerebral hemorrhage, develop unilateral spatial neglect syndrome (USN). USN is observed in 24% of patients with left-hemispheric stroke and 45% of patients with right-hemispheric lesions in the acute phase acute phase and in 20% of patients in the chronic phase. The presence of USN significantly complicates the rehabilitation process and negatively affects the functional outcomes. The complexity of USN correction is due to the heterogeneity of its manifestations and combination with other cognitive disorders. In 30-50% of patients with USN anosognosia is observed, in 60% - memory and attention disorders. Traditional methods of rehabilitation lead to significant improvement in 30-50% of patients with USN. The use of combined methods of treatment, including pharmacotherapy and non-medication methods, can improve efficacy by up to 70-80%. This indicates the need to develop and investigate new approaches to correct USN. Despite the growing number of studies in this area, there is still no unified approach to selecting the optimal method of USN correction for each individual patient. Different methods of rehabilitation may have different effects on neuroplasticity processes, which opens new perspectives for optimization of rehabilitation strategies.

Key facts

Study ID

NCT06802159

Run by

Federal Center of Cerebrovascular Pathology and Stroke, Russian Federation Ministry of Health

People needed

30

Starts

2025-01-09

Expected to finish

2025-12-15

Last updated by the study team

2025-06-22

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Normal cognitive development in accordance with age and educational level;
• diagnosis with codes I63, I61 (ICD);
• presence of unilateral spatial neglect syndrome in the neuropsychological status.

You may not qualify if…

• presence of mental and somatic pathology of severe degree and in decompensation stage;
• the presence of gross oculomotor disorders;
• presence of a sensory visual defect of moderate to severe severity

Where it is running

• Federal Center of Brain and Neurotechnologies of the FMBA of Russia — Moscow, Moscow, Russia (enrolling)
• Federal Center of Brain and Neurotechnologies of the FMBA of Russia — Moscow, Russia (enrolling)

Full record on ClinicalTrials.gov

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