ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer
Recruiting now · Not applicable
Conditions studied: Pancreatic Cancer
In brief
The goal of this clinical trial is to learn if total removal of the pancreas is a preferable alternative to partial removal in patients with cancer of the pancreatic head who are at high risk of pancreatic leakage. The main question it aims to answer is: Does total pancreas removal improve survival without reducing quality of life compared to partial removal? The only study specific procedures are the collection of 2 blood samples (7.5ml for each time point, preoperatively and during the hospitalisation) and the completion of the questionnaires.
Key facts
- Study ID
- NCT06801899
- Run by
- Insel Gruppe AG, University Hospital Bern
- People needed
- 170
- Starts
- 2026-06-01
- Expected to finish
- 2030-10-01
- Last updated by the study team
- 2026-07-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients (age ≥ 18 years) scheduled to undergo PD for highly suspected or histologically proven, resectable pancreatic ductal adenocarcinoma (PDAC), distal cholangiocarcinoma (DCC), and/or ampullary cancer (pancreaticobiliary type)
- Suspected pancreas anastomosis at high-risk for development of a postoperative pancreatic fistula (POPF) (grade "D" according to Schuh et al. (29): Estimation by CT scan, MRI, and/or Endoscopic Ultrasound
- Written informed consent
You may not qualify if…
- Duodenal carcinoma, ampullary cancer (intestinal type), neuroendocrine tumors, benign tumors, chronic pancreatitis
- Medical conditions that do not allow appreciation of the nature, scope, and possible consequences of the trial as judged by the investigator
- Pregnancy. A beta-Human Chorionic Gonadotropin (bHCG) pregnancy test must to be performed for women of child-bearing potential (defined as premenopausal women who have not undergone surgical sterilization)
- Inability to follow the study procedures, e.g., due to psychological disorders, dementia, etc.
Where it is running
- Department of Surgery and Transplantation, University Hospital Zürich — Zurich, Switzerland (enrolling)
- Department of General, Visceral and Transplantation Surgery, University Hospital Münster — Münster, Germany (enrolling)
- Department of General and Visceral Surgery, Kantonsspital Aarau — Aarau, Switzerland (enrolling)
- Department of Surgery, Kantonsspital Baden — Baden, Switzerland (enrolling)
- Department of Visceral Surgery, University Hospital Basel — Basel, Switzerland (enrolling)
- Inselspital, Bern University Hospital — Bern, Switzerland (enrolling)
- Department of Visceral Surgery, University Hospital Geneva — Geneva, Switzerland (enrolling)
- Department of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen — Sankt Gallen, Switzerland (enrolling)
- Department of Surgery, Stadtspital Triemli Zürich — Zurich, Switzerland (enrolling)
- Department of General and Visceral Surgery, University Hospital Ulm — Ulm, Germany
Full record on ClinicalTrials.gov
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