Urethral PeRfusion Index-Guided Hemodynamic ManagemenT in Patients Having Major Abdominal Surgery: the UPRIGHT Randomized Feasibility Trial

Recruiting now · Not applicable

Conditions studied: Urethral Perfusion Index, Tissue Perfusion, Microcirculation

In brief

We will perform this single-center pilot trial to determine if the intraoperative urethral perfusion index is higher in patients assigned to maintaining postinduction baseline urethral perfusion index than in patients assigned to routine care (with blinded urethral perfusion index monitoring). As pre-planned substudies, we will also assess the agreement between a) urethral perfusion index-derived pulse rate and heart rate measured with an electrocardiogram and b) between the urethral perfusion index and the peripheral perfusion index.

Key facts

Study ID

NCT06799832

Run by

Universitätsklinikum Hamburg-Eppendorf

People needed

116

Starts

2025-01-21

Expected to finish

2025-07-31

Last updated by the study team

2025-02-21

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• at least 45 years old
• scheduled for elective major abdominal surgery (involving visceral organs with an expected duration of at least 120 minutes)
• indication for an arterial catheter
• indication for an urinary catheter

You may not qualify if…

• Pregnancy
• Planned surgery: nephrectomy, liver or kidney transplantation surgery
• Patients who previously had surgery on the urethra or bladder
• Patients without clinical indication for continuous blood pressure monitoring with an intraarterial catheter

Where it is running

• University Medical Center Hamburg-Eppendorf — Hamburg, Germany (enrolling)
• University Medical Center Hamburg-Eppendorf — Hamburg, Germany

Full record on ClinicalTrials.gov

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