Role of Menopause in Thermoregulation

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Menopause, Aging

In brief

The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.

Key facts

Study ID

NCT06798571

Run by

Penn State University

People needed

24

Starts

2025-03-01

Expected to finish

2026-09-01

Last updated by the study team

2026-06-24

Who can join

Age: 42 and older, up to 64. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women ages 42-64

You may not qualify if…

• Chron's disease, diverticulitis, or similar gastrointestinal disease
• Abnormal resting exercise electrocardiogram (ECG)
• Tobacco use
• High-risk determined by the Atherosclerotic Cardiovascular Disease (CVD) Risk Factor
• Assessment
• Using hormone therapy
• Using hormonal contraceptives

Where it is running

• Noll Laboratory — University Park, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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