Different Cycles of Neoadjuvant PD-1 Blockades + Chemotherapy for Advanced Gastric Cancer
Recruiting now
Conditions studied: Gastric Adenocarcinoma
In brief
The goal of this observational study is to analyze the impact of different durations of neoadjuvant PD-1 inhibitor combined with chemotherapy on tumor regression and safety in patients with advanced gastric cancer. The main questions it aims to answer are: * Does the duration of neoadjuvant treatment influence tumor regression grading (TRG)? * How does treatment duration affect perioperative safety and clinical outcomes? Participants who have previously undergone neoadjuvant PD-1 inhibitor combined with chemotherapy followed by surgery as part of their routine medical care will have their clinical data retrospectively reviewed and analyzed.
Key facts
- Study ID
- NCT06798376
- Run by
- Chinese PLA General Hospital
- People needed
- 300
- Starts
- 2025-01-16
- Expected to finish
- 2025-01-31
- Last updated by the study team
- 2025-01-29
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Non-bedridden patients aged 18-90 years;
- Histologically confirmed gastric or gastroesophageal junction adenocarcinoma by biopsy;
- Evaluated as resectable advanced gastric cancer via CT, MRI, or laparoscopic exploration;
- No prior anti-tumor treatments such as chemotherapy, radiotherapy, or immunotherapy;
- No history of other malignancies within the past 5 years;
- Received at least one cycle of PD-1 inhibitor combined with chemotherapy preoperatively, with no restrictions on the specific PD-1 inhibitor or chemotherapeutic agents;
- Underwent radical gastrectomy after neoadjuvant therapy;
- No severe underlying diseases.
You may not qualify if…
- Incomplete or inaccessible clinical and pathological data;
- Postoperative pathology confirming non-gastric or non-gastroesophageal junction adenocarcinoma;
- Distant metastases present prior to treatment;
- Concurrent diagnosis of other malignancies.
Where it is running
- Chinese PLA General Hospital — Beijing, China (enrolling)
Full record on ClinicalTrials.gov
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