A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
Recruiting now · Phase 2
Conditions studied: Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
In brief
CIDP is an autoimmune disease. This means that the body's germ fighting (immune) system attacks itself. In CIDP, the immune system attacks the protective covering around the nerves called myelin. Over time, these nerves lose their ability to send signals to the muscles in the body. This leads to muscle weakness and loss of sensation in arms and legs among other symptoms. Participants with CIDP can be treated with a protein called immunoglobulin (or IG). TAK-411 is a special type of immune globulin G (hsIgG) that has been chemically changed. It is made from IG that comes from human plasma. This study will test if TAK-411 can decrease inflammation and improve symptoms of CIDP. The main aim of this study is to check how TAK-411 affects the physical functioning of adults with CIDP when compared with results of the placebo group of a historical trial. Participants may be treated with TAK-411 for up to 1 year (51 weeks) and will be followed up for 3 weeks after last dose. During the study, participants may visit their study clinic up to approximately 21 times.
Key facts
- Study ID
- NCT06798012
- Run by
- Takeda
- People needed
- 36
- Starts
- 2025-05-14
- Expected to finish
- 2028-06-08
- Last updated by the study team
- 2026-04-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California San Diego — La Jolla, California, United States (enrolling)
- California Pacific Medical Center — San Francisco, California, United States (enrolling)
- UF Health Neurology - Jacksonville — Jacksonville, Florida, United States (enrolling)
- Visionary Investigators Network — Miami, Florida, United States (enrolling)
- University of South Florida — Tampa, Florida, United States (enrolling)
- Emory University — Atlanta, Georgia, United States (enrolling)
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States (enrolling)
- Mayo Clinic Rochester — Rochester, Minnesota, United States (enrolling)
- The Curators of the University of Missouri on behalf of University of Missouri Health Care — Columbia, Missouri, United States (enrolling)
- The Washington University — St Louis, Missouri, United States (enrolling)
- Penn Blood Disorders Program - Hospital of The University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
- University of Washington — Seattle, Washington, United States (enrolling)
- Fundacion Oftalmologica de Santander - FOSCAL — Bucaramanga, Colombia
- University of Calgary — Calgary, Alberta, Canada
- University Health Network — Toronto, Ontario, Canada
- Neuro ClinicaS.A.S — Medellín, Antioquia, Colombia
- Hospital Universitario San Ignacio — Bogotá, D.C., Colombia
- Fundacion Valle del Lili — Cali, Valle del Cauca Department, Colombia
- Universidad del Rosario — Bogotá, Colombia
- Houston Methodist Research Institute — Houston, Texas, United States
Full record on ClinicalTrials.gov
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