Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients with Brain Lesions.

Recruiting now · Not applicable

Conditions studied: Glioblastoma, Glioma, Astrocytoma

In brief

Neurovascular uncoupling (NVU) represents a major source of potential bias for the identification of eloquent brain regions through activation procedures in blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). Same region shows proper pattern in glucose metabolism in victiny of brain lesions, investigated with positron emitted tomography with radiolabeled glucose (PET-FDG) This research project aims at investigating the mechanisms of NVU by using a multimodal noninvasive imaging approach in neurosurgical patients.

Key facts

Study ID

NCT06797661

Run by

Erasme University Hospital

People needed

40

Starts

2025-02-17

Expected to finish

2026-12-31

Last updated by the study team

2025-02-19

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients in the study include prior imaging showing a potentially resectable intra-cerebral mass lesion. Patient has to be included before surgery, chemotherapy and radiation

You may not qualify if…

• previous brain surgery
• respiratory failure
• Asthma
• Claustrophobia
• Previous adverse reaction to gadovist (contrast agent)
• Pregnancy and Breath feeding
• Diabetes (type I and II)

Where it is running

• HUB-Erasme Hospital — Brussels, Belgium (enrolling)

Full record on ClinicalTrials.gov

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