Non-invasive Detection of Acute Cell-mediated Graft Rejection in Pediatric Heart Transplant Recipients

Recruiting now

Conditions studied: Pediatric Heart Transplant

In brief

Acute cardiac rejection is currently diagnosed by endomyocardial biopsy (EMB), but multiparametric cardiac magnetic resonance (CMR) may be a non-invasive alternative by its capacity for myocardial structure and function characterization. Our primary aim was to determine the utility of multiparametric CMR in identifying acute graft rejection in paediatric heart transplant recipients. The second aim was to compare textural features of parametric maps in cases of rejection versus those without rejection.

Key facts

Study ID

NCT06795958

Run by

IRCCS Azienda Ospedaliero-Universitaria di Bologna

People needed

30

Starts

2023-12-12

Expected to finish

2029-12-31

Last updated by the study team

2025-01-28

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• children and young adults (transplanted when they were ≤ 18 years) who undergo an EMB for routine surveillance without contraindications to contrast-enhanced CMR

You may not qualify if…

• We also don't recruit recipients who were < 3 months post-heart transplantation to reduce the possibility of confounding from ischemia-reperfusion injury that occurs with the heart transplant procedure

Where it is running

• IRCCS Azienda Ospedaliero-Universitaria di Bologna — Bologna, Italy (enrolling)

Full record on ClinicalTrials.gov

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