PRogression of Atheroma Evaluated by CT Angiography and IntraCoronary Imaging tEchniques
Recruiting now
Conditions studied: Coronary Arterial Disease (CAD), Coronary Arteriosclerosis
In brief
This is a combined cohort study with retrospectively and prospectively enrolled coronary artery disease (CAD) patients. All the patients will undergo clinical follow-up for up to 5 years, and repeat coronary CTA will be conducted after 2 years. Comprehensive morphological and functional plaque analysis will be performed. The impact of these morphological and functional parameters, alongside cardiometabolic factors and pharmacological treatments on plaque progression and the occurrence of major adverse cardiovascular events (MACEs) will be analyzed. In addition, intracoronary imaging techniques will be used to improve the accuracy of plaque analysis by coronary CTA.
Key facts
- Study ID
- NCT06794684
- Run by
- Ruijin Hospital
- People needed
- 50000
- Starts
- 2016-01-01
- Expected to finish
- 2030-05-31
- Last updated by the study team
- 2025-01-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Clinically significant angina pectoris, or suspected CAD
- Receive coronary CTA scan, with a visible plaque (defined as ≥25% diameter stenosis) in major coronary arteries.
You may not qualify if…
- Unsuitable for coronary CTA (such as severe renal impairment, uncontrolled thyroid condition, allergic to iodine, etc.)
- Receive percutaneous coronary intervention (PCI) within 6 months
- Prior history of myocardial infarction or heart failure
- Prior history of percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG)
- Abnormal liver function (serum alanine aminotransferase [ALT] level exceeding 3 times the upper limit of normal) or abnormal kidney function (eGFR ≤30 ml/min)
- Familial hypercholesterolemia
- Estimated survival ≤ 1 year
- Malignant tumor
- Pregnant or lactation, or have the intention to give birth within one year
- Poor coordinance, unable to follow-up
Where it is running
- CAAC East China Aviation Personnel Medical Appraisal Center, Civil Aviation Shanghai Hospital — Shanghai, China (enrolling)
- Ruijin Hospital, Shanghai Jiaotong University School of Medicine — Shanghai, China (enrolling)
Full record on ClinicalTrials.gov
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