Comparison of the Efficacy of Celiac Plexus Blockade, ESP and Lidocaine Infusion Under OFA

Recruiting now · Not applicable

Conditions studied: Regional Anaesthesia, Anesthesia and Analgesia

In brief

Modern anesthesiology, in search of alternatives to opioid-based pain management, is turning to low-opioid and non-opioid protocols. Replacing opioids with non-opioid analgesics, co-analgesics, and regional and local anesthesia techniques allows avoiding the adverse effects of opioids while maintaining satisfactory analgesia. This is of particular importance in bariatric surgery, where reducing the incidence of respiratory depression, sedation, opioid hyperalgesia, and postoperative nausea and vomiting is a priority. Standard non-opioid anesthesia (OFA) includes ketamine, lidocaine, and dexmedetomidine infusions, while regional techniques additionally reduce the need for analgesics. Despite the widespread use of these methods, there is no clear data on the superiority of any of them in bariatric procedures.

Key facts

Study ID

NCT06793527

Run by

Jagiellonian University

People needed

300

Starts

2025-02-06

Expected to finish

2026-12-31

Last updated by the study team

2025-04-04

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients over 18 years who underwent laparoscopic bariatric surgery
• Must be able to sign agreement for study

You may not qualify if…

• Patients with a history of allergic reactions to drugs
• Patients with a history of drug addiction
• Patients with chronic pain who require analgesics
• History of hospitalization for psychiatric disorders
• Preoperative pulse oximetry (SpO2) < 95 %
• bradycardia (HR<50bpm)
• hypotension
• atrioventricular block
• intraventricular or sinus block
• Blood clotting disorders
• Pregnant/lactating women
• Cognitive impairment
• Unable to read consent

Where it is running

• Department of Intensive Interdisciplinary Care, Collegium Medicum, Jagiellonian University — Krakow, Lesser Poland Voivodeship, Poland (enrolling)

Full record on ClinicalTrials.gov

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