Anxiety During Abstinence in AUD
Recruiting now · Early Phase 1
Conditions studied: Alcohol Use Disorder
In brief
The goal of this study is to better understand the underlying neurobiological basis of anxiety that emerges during abstinence in patients with alcohol use disorder (AUD). The main questions it aims to answer are: 1. To characterize anxiety itself as well as anxiety related-neurobiological circuitry in early abstinence in AUD 2. To examine how anxiety and anxiety related-neurobiological circuitry change over the course of abstinence in AUD Researchers will recruit both participants with AUD and healthy volunteers. The participants with AUD will be prescribed disulfiram, a medication that helps participants with AUD stay abstinent. Healthy volunteers will not receive antabuse. Patients with AUD will undergo fMRI scanning both after 1 week and 3 months of disulfiram treatment. Healthy volunteers will undergo fMRI once.
Key facts
- Study ID
- NCT06793488
- Run by
- Columbia University
- People needed
- 60
- Starts
- 2025-09-15
- Expected to finish
- 2029-08-30
- Last updated by the study team
- 2026-02-10
Who can join
Age: 21 and older, up to 55. Sex: any. Healthy volunteers: accepted.
Where it is running
- Columbia University Irving Medical Center — New York, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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