Effect of Mechanical Ventilation on Radiofrequency Ablation in Atrial Fibrillation

Recruiting now

Conditions studied: Radiofrequency Ablation, Atrial Fibrillation, Mechanical Ventilation

In brief

Radiofrequency ablation (RFA) for atrial fibrillation (AF) is performed under general anesthesia. The success of the procedure depends on the safe contact of the catheter electrode with the myocardium. Movement of the catheter tip due to respiratory changes can result in inadequate lesion formation and AF recurrence. The success of AF ablation depends on the adequacy of energy delivered to the myocardium and the durability of pulmonary vein isolation (PVI). Poor energy delivery and tissue heating during ablation are a major cause of procedural failure in RFA. To improve the success of the PVI procedure, efforts are underway to optimize catheter stability and contact force. However, catheter force and stability are influenced by respiration-induced thoracic motion, highlighting the importance of controlled breathing for further optimization. Fluoroscopy and ablation times during electroanatomic mapping-guided AF ablations improved with controlled mechanical ventilation. General anesthesia improved catheter contact. Low tidal volume, high respiratory rate (FCV), pressure controlled mechanical ventilation (PCV), volume controlled mechanical ventilation (VCV), pressure controlled volume assured mechanical ventilation (PRVC) can be used in investigators' hospital. The literature offers no definitive proof that one ablation procedure is superior to another.

Key facts

Study ID

NCT06791915

Run by

Kocaeli City Hospital

People needed

50

Starts

2025-01-01

Expected to finish

2025-08-01

Last updated by the study team

2025-01-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosed with atrial fibrillation
• planned to receive radiofrequency ablation treatment under general anesthesia
• all patients over 18 years of age

You may not qualify if…

• Patients undergoing ablation under sedation and/or local anesthesia

Where it is running

• Kocaeli City Hospital — Kocaeli, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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