Effect of Supplement on Appetite and GLP-1
Completed · Not applicable · Has a placebo group
Conditions studied: Hunger
In brief
Study Summary The goal of this study is to understand whether a dietary supplement containing L-arginine, resveratrol, tart cherry, and vitamin C reduces hunger and increases the release of GLP-1, a hormone associated with appetite suppression and improved glucose regulation. The study will also explore the metabolic effects of the supplement. Main Questions: 1. Does the supplement reduce hunger more effectively than a placebo? 2. Does it enhance GLP-1 release in individuals with overweight or obesity? Participants: * Age: 18-60 years * Body Mass Index (BMI): 25-40 kg/m² * Total participants: 25 * Must maintain usual eating and activity habits during the study. Study Design: * Conditions Tested: High-dose supplement, low-dose supplement, and placebo. * Participants will undergo three separate 2-hour lab visits, each after fasting for 8 hours. * During each visit: * Consume the assigned supplement or placebo. * Eat a standardized meal after a 60-minute rest. * Provide blood samples at eight time points to measure GLP-1 and other metabolic markers. * Rate hunger using a 7-point scale. Benefits and Risks: * Benefits: Participants may not directly benefit, but the findings could lead to new appetite-suppressing supplements that aid in weight loss. * Risks: Include discomfort from blood draws, possible gastrointestinal side effects from the supplement, and allergic reactions. Measures are in place to minimize these risks, such as pre-screening for allergies and using trained personnel for blood collection. This study is triple-blinded, meaning neither the participants, researchers, nor analysts will know which condition is being tested during each visit. Data collected will be anonymized to protect participant privacy.
Key facts
- Study ID
- NCT06790771
- Run by
- Texas Christian University
- People needed
- 25
- Starts
- 2025-01-15
- Expected to finish
- 2026-03-15
- Last updated by the study team
- 2026-05-28
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Participants must meet all the following conditions to be eligible for the study:
- Age: 18-60 years old.
- BMI (Body Mass Index): Between 25 and 40 kg/m².
- Diet and Activity Stability: Willing to maintain current dietary and physical activity habits for the duration of the study.
You may not qualify if…
- Participants will be excluded from the study if any of the following conditions apply:
- Recent Weight Change: Lost or gained more than 5% of body weight in the last 3 months.
- Pregnancy or Lactation: Pregnant or breastfeeding women.
- Medical Conditions:
- Kidney disease (Chronic Kidney Disease or End-Stage Renal Disease).
- Herpes simplex.
- Uncontrolled diabetes (HbA1c >7%).
- Thyroid disorders or taking thyroid medications.
- Type 1 diabetes.
- Cushing syndrome.
- Cirrhosis or hepatitis.
- Chronic obstructive pulmonary disease (COPD).
- Dementias.
- Active autoimmune diseases (e.g., lupus, rheumatoid arthritis).
- Crohn's disease or ulcerative colitis.
- Celiac disease.
- Allergies or Sensitivities:
- Known allergies to any components of the supplement or standardized meal.
- Medications: Currently taking any of the following:
- Supplements or medications for weight loss.
- Antihypertensive, antidiabetic, or antihyperlipidemic medications.
- Erectile dysfunction medications.
- Blood thinners (e.g., aspirin, warfarin).
- Medications containing nitric oxide or nitroglycerin.
- Drugs affecting GLP-1 levels, such as GLP-1 receptor agonists, insulin, certain antidepressants, or corticosteroids.
Where it is running
- Texas Christian University — Fort Worth, Texas, United States
Full record on ClinicalTrials.gov
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