Assessment of Pro-Resolution Mediator Levels in Periodontitis Stage III and IV Before and After Periodontal Therapy
Recruiting now · Not applicable
Conditions studied: Peridontal Disease
In brief
This study aims to assess Pro-Resolution Mediator levels during non-surgical periodontal therapy in individuals with Stage III and IV periodontitis, comparing them to healthy subjects. Periodontitis, a chronic inflammatory condition affecting tooth-supporting tissues, can lead to tooth loss and systemic complications. Understanding the role of pro-resolving lipid mediators in inflammation resolution may offer insights into therapeutic benefits associated with these mediators.
Key facts
- Study ID
- NCT06789458
- Run by
- Cairo University
- People needed
- 22
- Starts
- 2022-10-15
- Expected to finish
- 2025-10-14
- Last updated by the study team
- 2025-01-23
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Inclusion criteria:
- Adult patients above 18 years old.
- Interdental CAL at site of greatest loss ≥5 mm or extending to middle third of the root.
- Interdental CAL at site of greatest loss ≥8 mm or extending to apical third of the root.
- Probing depth ≥6 mm.
- Vertical bone loss ≥3 mm.
- Tooth loss due to periodontitis of ≤4 teeth. (Periodontitis Stage III)
- Tooth loss due to periodontitis of ≥5 teeth. (Periodontitis Stage IV)
- Furcation involvement Class II or III Moderate ridge defect.
You may not qualify if…
- 1. Pregnancy or lactation. 2. Smoking more than 20 cigarettes. 3. Immuno-inflammatory conditions of the skin and oral mucosa 4. systemic conditions affecting bone turnover and periodontal health status (e.g. endocrine and connective tissue diseases, bisphosphonate antiresorptive therapy, gastrointestinal diseases related to nutrition and mineral metabolism) 5. Periodontal or orthodontic treatment at least 6 months before the start of the study 6. Use of anti-inflammatory and antimicrobial agents within 3 months before sampling
- Inclusion criteria for healthy group:
- Systemically healthy patients.
- Patients with an age range between 16 to 80 years.
- Patients have a minimum of 20 teeth.
- Less than 10% bleeding sites with probing depths ≤3 mm.
- absence of erythema, oedema.
Where it is running
- Faculty of Dentistry-Cairo University — Manial, Cairo Governorate, Egypt (enrolling)
- faculty of dentistry Cairo university — Cairo, Egypt (enrolling)
Full record on ClinicalTrials.gov
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