Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial
Recruiting now · Not applicable
Conditions studied: Postoperative Delirium (POD), Diabetes
In brief
The present study is a multicenter， randomized controlled clinical trial, which plans to enroll 450 diabetic patients aged more than 60 years. The participants will be randomly assigned in a 1:1 ratio and will receive either propofol or sevoflurane for intraoperative anesthesia maintenance to evaluate the impact of these two anesthetic drugs on postoperative delirium. The aim of our study is to explore whether the use of propofol for anesthesia maintenance in elderly diabetic patients undergoing elective non-cardiac major surgery can reduce the incidence of postoperative delirium. This study will provide new perspectives for improving perioperative management in elderly diabetic patients and optimizing anesthesia management strategies to reduce the risk of postoperative delirium.
Key facts
- Study ID
- NCT06788743
- Run by
- Xijing Hospital
- People needed
- 450
- Starts
- 2025-06-01
- Expected to finish
- 2026-05-31
- Last updated by the study team
- 2026-04-16
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥60 years
- Elective surgery (with an expected duration of 2 hours or more)
- ASA grade Ⅰ-Ⅲ
- Voluntary participation and informed consent obtained
- Diabetes mellitus
You may not qualify if…
- Pre-operative BMI≥35 kg/m² (Class II obesity or above)
- Severe hepatic dysfunction (Child-Pugh class C) or pre-operative dialysis-dependent renal dysfunction
- Known neurological or psychiatric diseases (Parkinson's disease, depression, schizophrenia), or cognitive impairment (dementia)
- Severe visual or auditory impairments, language barriers, or patients who cannot cooperate
- Long-term use of sedatives, antipsychotic drugs, or long-term alcohol abuse
- Neurosurgical patients
- Patients with a known allergy to the drugs used in this study or those suspected of having propofol infusion syndrome
Where it is running
- The First Affiliated Hospital of Air Force Medical University — Xi’an, Shanxi, China (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.