Efficacy of Esketamine for Patients With Irritable Bowel Syndrome
Recruiting now · Not applicable
Conditions studied: Irritable Bowel Syndrome
In brief
To explore the efficacy of a single low dose of esketamine for patients with irritable bowel syndrome (IBS).
Key facts
- Study ID
- NCT06788444
- Run by
- Beijing Tiantan Hospital
- People needed
- 552
- Starts
- 2025-09-18
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2025-09-10
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age of 18 - 60 years;
- American Society of Anesthesiologists (ASA) physical status of I - II;
- Body Mass Index (BMI) of 15 - 30;
- Scheduled for colonoscopy;
- Positive screening results according to the Rome IV diagnostic criteria for IBS;
- Patients who met Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for Anxiety disorder (ANXD) and/or major depressive disorder (MDD) .
You may not qualify if…
- GastrointestinalTract (GI) bleeding;
- Any organic lesions confirmed by clinical examination, laboratory examination or colonoscopy；
- A previous diagnosis of colon cancer, infammatory bowel disease or coeliac disease;
- A history of weight loss (at least 10%) within six months;
- A history of abdominal surgery (other than hernia repair or appendectomy);
- Participate in other clinical trials within 3 months;
- Patients older than 55 years of age who have not undergone a colonoscopy in the past 5 years；
- Mental disorder patients with severe personality disorder, active suicidal ideation and history of self-harm within 1 year;
- Allergy or any contraindications to the drugs used in the study, such as severe cardiovascular disease, refractory hypertension, or hyperthyroidism;
- Drinking more than 50 units (1 unit refers to 10ml of pure alcohol) per week;
- Pregnancy or breastfeeding.
Where it is running
- Beijing Tiantan Hospital — Beijing, Beijing Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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