Communicating About Nicotine Reduction in Cigarettes

Recruiting now · Not applicable

Conditions studied: Tobacco Products, Smoking Behavior, Cigarette Use

In brief

The goal of this clinical trial is to learn how a messaging campaign about reduced nicotine cigarettes and policy, combined with the use of very low nicotine cigarettes (VLNCs), affects smoking behavior and attitudes among adult smokers. The study also aims to assess the efficacy of the messages in different populations, including smokers with past-month serious psychological distress (SPD), low socioeconomic status (SES), and those in neither category. The primary hypothesis is: exposure to messages in combination with VLNC use will lead to less cigarettes use compared to VLNCs without messages. Researchers will compare: The effects of receiving VLNCs with messages (treatment group) to receiving VLNCs without messages (control group). Participants will: Complete a baseline survey and be randomly assigned to one of two groups: treatment (VLNCs + messages) or control (VLNCs only). Attend weekly study visits for surveys, breath samples, and receive supply of VLNCs , either with or without the messaging campaign. Complete brief daily surveys through text messages.

Key facts

Study ID

NCT06787937

Run by

Georgia State University

People needed

1230

Starts

2025-09-11

Expected to finish

2029-01-31

Last updated by the study team

2025-10-29

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 21+ years
• Current smoker (self-report as having smoked 100 cigarettes in their lifetime and currently smoking on 27+ days out of past 30, expired breath carbon monoxide [CO] ≥6ppm to assess regular smoking)
• Can speak, read, and write in English
• Available for period of study
• Willing to try novel research cigarettes

You may not qualify if…

• Pregnancy or lactation
• Member of the same household as a study subject
• Unwilling to use research cigarettes as part of the trial

Where it is running

• Georgia State university — Atlanta, Georgia, United States (enrolling)
• Emory University — Atlanta, Georgia, United States (enrolling)

Full record on ClinicalTrials.gov

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