Effects of Nicorandil on Microvascular Dysfunction in Patients With STEMI Undergoing Primary PCI
Starting soon · Phase 4 · Has a placebo group
Conditions studied: STEMI - ST-segment Elevation Myocardial Infarction
In brief
Despite the success of restoration of epicardial blood flow by the primary percutaneous coronary intervention (PPCI), approximately one half of patients with ST-segment elevation myocardial infarction (STEMI) have failed myocardial reperfusion, namely microvascular dysfunction. Previous studies have shown that coronary microvascular damage significantly impacts the prognosis of patients with STEMI. Therefore, restoration of microvascular function is quite important during the PPCI procedures. Recent clinical trials found that nicorandil, a hybrid ATP-sensitive potassium channel opening agent, improved microvascular function, prevented no-reflow phenomenon, and had beneficial cardioprotective effects in patients receiving PPCI. However, there was a lack of evidence on the protective effects of nicorandil on microvascular function. The coronary angiography-derived IMR (AMR) is a novel wire-free technology developed for fast computation of IMR in patients undergoing coronary angiography, thereby enabling the quantification of coronary microcirculation of patients. This study is aimed to investigate the effects of nicorandil on microvascular dysfunction as evaluated by AMR in patients with STEMI.
Key facts
- Study ID
- NCT06787430
- Run by
- China National Center for Cardiovascular Diseases
- People needed
- 170
- Starts
- 2026-03-01
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-03-12
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age between 18-80
- Diagnosis of STEMI and indicating for primary PCI
- Diagnostic coronary angiography showed definite culprit vessel and primary PCI was planned to treat the culprit vessel.
- Reference vessel diameter of culprit vessel was greater than 2.0 mm
- There was no flow-limiting stenosis for the non-culprit vessels.
- Understand the aim of this trial and agree to sign the informed consent form.
You may not qualify if…
- Acute in- stent thrombosis or in-stent stenosis lesions of culprit vessel.
- Balloon angioplasty rather than stent was planned for the culprit vessel.
- Allergic to nicorandil or systolic arterial pressure was less than 85mmHg before procedure
- Vessel with twisted shape that was unable to be measured using AMR
- Oral or intravenous use of nicorandil within one month.
- Cardiac shock needing mechanical support.
- Severely hepatic dysfunction.
- Severely renal failure needing hemodialysis.
- Contraindicated for coronary angiography or primary PCI.
- Culprit vessels of left main or graft vessels.
- Pregnant or nursing.
- Others that investigators think should excluded.
Full record on ClinicalTrials.gov
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