Di-PKD: A Pilot Trial of Dietary Intervention in Patients With Autosomal Dominant Polycystic Kidney Disease

Starting soon · Not applicable

Conditions studied: Autosomal Dominant Polycystic Kidney Disease (ADPKD)

In brief

The goal of this interventional study is to evaluate the impact of a specific diet (low salt, limited caffeine, high potassium, low phosphate, limited protein, limited carbohydrate intake, adequate water intake) on changes in serum and urinary biomarkers, total kidney volume (TKV), and cyst progression in subjects with autosomal dominant polycystic kidney disease (ADPKD). Researchers will compare the results of subjects in the study diet (interventional) arm to the results of subjects in the regular diet (control) arm.

Key facts

Study ID

NCT06786260

Run by

Loma Linda University

People needed

30

Starts

2026-05-01

Expected to finish

2027-04-01

Last updated by the study team

2026-01-30

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed diagnosis of ADPKD
• Genetic testing confirmation of PKD1 or PKD2
• eGFR >30mL/1.73m2
• Willingness to adhere to a preconditioning diet for 1 week and ability to complete the study
• Mayo Clinic Imaging Classification (MCIC): 1C, 1D, 1E

You may not qualify if…

• History of dietary non-adherence
• Subjects on Tolvaptan
• Comorbidities that could interfere with participation (Diabetes, Heart Failure (EF<30%) Advanced Chronic Kidney Disease (CKD) Stage 4 and higher)

Where it is running

• Loma Linda University Health — Loma Linda, California, United States

Full record on ClinicalTrials.gov

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