A Phase 2 Study to Assess STP938 (Dencatistat) as a Monotherapy in Adults With High Risk Essential Thrombocythaemia - The VECTRA Trial
Recruiting now · Phase 2
Conditions studied: Essential Thrombocythaemia
In brief
The goal of this clinical trial is to learn if the drug STP938 works to treat adults with high risk essential thrombocythaemia (ET) who are resistant to, or intolerant of, hydroxycarbamide (also known as hydroxyurea) therapy. The trial will also learn about the safety of STP938. The main questions the trial aims to answer are: * Does STP938 control platelet counts * Does STP938 control platelet counts without inducing unwanted side effects Participants will: * Take STP938 every day for up to 12 months. * Visit the clinic once every week for the first month, then every 2 weeks for checkups and tests. * Complete a questionnaire about symptoms once a month.
Key facts
- Study ID
- NCT06786234
- Run by
- Step Pharma, SAS
- People needed
- 50
- Starts
- 2025-06-18
- Expected to finish
- 2028-09-30
- Last updated by the study team
- 2026-06-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Southampton Hospital — Southampton, United Kingdom (enrolling)
- CHU Brest — Brest, France (enrolling)
- Institut Paoli-Calmettes — Marseille, France (enrolling)
- CHU Nantes — Nantes, France (enrolling)
- CHU Nice — Nice, France (enrolling)
- CHU Nîmes — Nîmes, France (enrolling)
- Hôpital Saint-Louis — Paris, France (enrolling)
- Gustave Roussy — Villejuif, France (enrolling)
- Royal Hallamshire Hospital — Sheffield, South Yorkshire, United Kingdom (enrolling)
- University Hospital of Wales — Cardiff, United Kingdom (enrolling)
- Imperial College London / Hammersmith Hospital — London, United Kingdom (enrolling)
- Sarah Cannon Research Institute — London, United Kingdom (enrolling)
- Cancer and Haematology Centre, Churchill Hospital — Oxford, United Kingdom (enrolling)
- Hôpital de la Milétrie, CHU — Poitiers, New Aquitaine, France
Full record on ClinicalTrials.gov
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