EXploratory Study on Postprandial Energy Metabolism

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Obesity and Overweight, Moderately Obese

In brief

This exploratory, double-blinded clinical trial on 66 randomized adults aged 50 to 70 years with moderate overweight or obesity but considered metabolically healthy will consist of comparing metabolic and microbiota parameters before and after 3 months of consumption of a probiotic or a placebo.

Key facts

Study ID: NCT06786052
Run by: Lallemand Health Solutions
People needed: 66
Starts: 2025-04-07
Expected to finish: 2028-02-01
Last updated by the study team: 2026-05-28

Who can join

Age: 50 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Man or woman;
Age between 50 and 70 years old (inclusively);
Postmenopausal women, i.e. with amenorrhea for more than a year with no identified cause
BMI between 27 and 34.9 kg/m2 (inclusively);
Stable weight in the last 3 months (+/- 5% of total body weight);
Waist circumference ≥ 80 cm for women, ≥ 94 cm for men;
Sedentary to moderately active (less than 30 minutes of moderate physical activity, 3 times a week);
Agreeing not to consume fermented or supplemented foods (including bifidus yogurts and other foods supplemented with probiotics), dietary supplements (high in fiber (prebiotics), high protein, or other food supplements that may interact with the gut microbiota or energy metabolism), laxatives and any substance that can control metabolic parameters such as weight, blood glucose or lipid metabolism during the study period (from the screening visit);
Agreeing to receive probiotics or placebo supplementation randomly;
Able to understand the information given, read and write in French and have signed the informed consent form;
Agreeing to submit to the entire study protocol;
Having fibre consumption (through diet or supplementation) of less than 30g/day;
Having a freezer to store stool samples before the visit.

You may not qualify if…

Participant with unstable medical or psychological conditions that, in the opinion of the investigator, could lead the participant to be non-compliant or uncooperative during the study or that could compromise the safety or participation in the study (according to articles L.1121-6, L.1121-8, L.1121-9 and L1122-1-2 of the Public Health Code);
Presence of pathology detectable on clinical examination and medical questioning that may interfere with the study endpoints;
Alcohol consumption exceeding 30g of alcohol/day (1 dose of alcoholic beverage = 10g of alcohol) or abuse or dependence on another proven drug;
Tobacco consumption (or vaping equivalent) > to 5 cigarettes per day and inability to restrict smoking or vaping on the exploratory days provided for in the protocol;
Failure to comply with the exclusion period for another study specified in the "national volunteer file";
Adult subject to a legal protection measure (guardianship, curatorship);
Person deprived of liberty by a judicial or administrative decision;
Person who has exceeded the annual amount of compensation in the year for participation in research protocols;
Person not affiliated to a social security system or beneficiary of a similar system;
Absence of valid approved health proof(s) in the event of government measures in an exceptional epidemic situation;
Person with a specific diet (vegetarian, lacto-vegetarian, vegan, high-protein, etc.);
People consuming food supplements (pre or probiotics, or minerals (divalent cations such as magnesium and calcium)) regularly during the month prior to the screening visit;
Blood donation within 2 months prior to the screening visit;
Claustrophobic to the point that indirect calorimetry measurement cannot be done;
Person with limited venous access that can make it difficult to draw blood and insert a catheter;
Type 1 or 2 diabetes;
Systolic blood pressure ≥140 mmHg measured during the screening visit and mean systolic blood pressure from self-measurement over 3 days ≥140 mmHg;
Diastolic blood pressure≥ 90 mmHg measured during the screening visit and mean diastolic blood pressure from self-measurement over 3 days ≥90 mmHg;
Treatment for hypertension or dyslipidemia;
Known endocrine pathology that may interfere with carbohydrate metabolism (uncontrolled dysthyroidism, acromegaly, hypercorticism, etc.);
People with gastrointestinal pathologies with an inflammatory component or associated with malabsorption;
People suffering from bloody diarrhoea;
Exocrine pancreatic insufficiency;
People who have had intestinal or abdominal surgery (apart from appendectomy and simple hernias), bariatric surgery (gastric banding, calibrated vertical gastroplasty and sleeve gastrectomy accepted if done more than 5 years ago);
Severe eating disorders (e.g., anorexia/bulimia, uncontrolled binge eating syndrome, noctophagia);

Where it is running

Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA) — Pierre-Bénite, Auvergne-Rhône-Alpes, France (enrolling)

Full record on ClinicalTrials.gov

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