Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty

Recruiting now · Phase 4

Conditions studied: Acute Postoperative Pain, Surgery

In brief

This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty. Investigators will randomize participants to either continuous nerve block or single injection nerve block for the adductor canal preoperatively. They will assess differences in pain (measured in numeric rating scale), opioid consumption, and physical therapy milestones from postoperative day 0 to 7.

Key facts

Study ID

NCT06784882

Run by

University of California, San Diego

People needed

40

Starts

2025-06-01

Expected to finish

2025-12-01

Last updated by the study team

2025-06-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult participants of at least 18 years of age
• Undergoing a primary, unilateral, total knee arthroplasty
• Planned single-injection adductor canal nerve block
• Weight > 50 kg (to minimize the risk of local anesthetic toxicity)

You may not qualify if…

• chronic opioid or tramadol use: daily oxycodone equivalents > 20 mg for > 4 weeks
• neuro-muscular deficit of the surgical limb
• moderate pain (NRS > 3) in an anatomic location other than the surgical site
• planned hospital admission following surgery
• history of opioid misuse
• those who lack capacity to complete informed consent
• inability to contact the investigators during the treatment period, and vice versa (e.g., lack of telephone access)
• incarceration
• pregnancy
• allergy to amide local anesthetics

Where it is running

• University of California, San Diego — La Jolla, California, United States (enrolling)

Full record on ClinicalTrials.gov

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