Preventive Use of PIPAC in Locally Advanced Gastric Cancer.

Recruiting now · Not applicable

Conditions studied: Gastric Cancer

In brief

Gastric cancer is the fifth most common cancer worldwide and the third leading cause of cancer-related mortality. In patients with locally advanced gastric cancer, multimodal treatment strategies, including perioperative chemotherapy, have significantly improved survival rates. Despite these advances, peritoneal carcinomatosis (PC) remains a serious problem, occurring in 60% of cases after radical surgery. PC is associated with poor prognosis and limited treatment options. Intra-abdominal chemotherapy, particularly hyperthermic intraperitoneal chemoperfusion (HIPEC), has demonstrated advantages in the treatment of PC. However, a new technique, pressurized intraperitoneal aerosolized chemotherapy (PIPAC), is emerging as a promising alternative. PIPAC delivers chemotherapeutic agents directly to the peritoneal surface as an aerosol, allowing deeper penetration of drugs into tumor implants while minimizing toxicity and invasiveness. This study hypothesizes that the addition of PIPAC as a preoperative treatment for patients with locally advanced gastric cancer may reduce the incidence of peritoneal carcinomatosis compared to standard therapy. The primary objective of this study is to determine whether preoperative PIPAC reduces the incidence of peritoneal carcinomatosis in these patients.

Key facts

Study ID

NCT06784765

Run by

National Research Oncology and Transplantology Center, Kazakhstan

People needed

160

Starts

2025-01-15

Expected to finish

2027-12-01

Last updated by the study team

2025-05-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed informed consent
• Aged 18-70 years
• ECOG performance status 0-2
• Histologically confirmed adenocarcinoma of the stomach (T3-4N0-3M0)
• Negative peritoneal cytology from diagnostic laparoscopy
• No prior chemotherapy or radiotherapy

You may not qualify if…

• Presence of distant metastases
• Positive peritoneal cytology
• Previous cancer treatment (chemotherapy, radiotherapy, or surgery)
• Severe comorbid conditions contraindicating surgery or chemotherapy
• Pregnancy or lactation
• Known hypersensitivity to study drugs

Where it is running

• National Research Oncology Centre — Astana, Kazakhstan (enrolling)

Full record on ClinicalTrials.gov

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