Effects of Enavogliflozin on Coronary Microvascular and Cardiac Function in Obesity

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Obesity and Type 2 Diabetes

In brief

The goal of this study is to analyze the effects of enavogliflozin on heart function and coronary microvascular function in obese patients compared to a placebo, and to evaluate the improvement in cardiopulmonary exercise capacity in these patients.

Key facts

Study ID

NCT06782139

Run by

Korea University Anam Hospital

People needed

30

Starts

2025-01-20

Expected to finish

2025-12-31

Last updated by the study team

2025-09-02

Who can join

Age: 20 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Left ventricular ejection fraction (LVEF) < 50%
• History of coronary artery disease, or patients who have undergone coronary artery intervention or coronary artery bypass grafting.
• Patients with suspected obstructive coronary artery disease, including those with chest pain and positive stress test results (e.g., exercise treadmill test, dobutamine stress echocardiography, myocardial perfusion imaging).
• Second-degree or higher atrioventricular block, symptomatic bradycardia, sick sinus syndrome, or Wolff-Parkinson-White syndrome.
• Chronic kidney disease (GFR < 30 mL/min/1.73 m²) or end-stage renal disease on hemodialysis or peritoneal dialysis.
• Asthma, chronic obstructive pulmonary disease, or primary pulmonary hypertension.
• Moderate or severe valvular heart disease or congenital heart disease, or patients with a history of open-heart surgery.
• Active cancer within the last 5 years, or patients currently receiving chemotherapy.
• Vasculitis associated with autoimmune diseases, such as systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA).
• Patients who cannot undergo exercise testing, such as treadmill or bicycle ergometer testing.
• Use of any other SGLT2 inhibitors (e.g., dapagliflozin, empagliflozin) within the past 6 months, or a known allergy to these drugs.
• Pregnant or breastfeeding women.
• Women planning pregnancy during the study period (or within 24 weeks from the start of the study, including the 12-week observation period).
• Acute urinary tract infection at the time of enrollment.

Where it is running

• Korea University Anam Hospital — Seoul, South Korea (enrolling)

Full record on ClinicalTrials.gov

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