Improving the Anabolic Action of Plant-based Foods Using Complementary Proteins
Completed · Not applicable
Conditions studied: Health, Recreational Activities, Muscle Protein Synthetic Response to Protein, Muscle Protein Synthesis
In brief
In a crossover design 10 young healthy adults (20-35 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise. Immediately after exercise participants will ingest either 246 g of rice and beans or its constituent macronutrients as isolated amino acids, carbohydrates, fiber, and fat. Repeated blood and muscle biopsies will be collected to determine amino acid concentrations, anabolic signaling and myofibrillar protein synthesis rates during the trials.
Key facts
- Study ID
- NCT06781723
- Run by
- University of Illinois at Urbana-Champaign
- People needed
- 11
- Starts
- 2024-09-05
- Expected to finish
- 2025-04-01
- Last updated by the study team
- 2025-05-08
Who can join
Age: 20 and older, up to 35. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 20-35 yrs
- Pre-menopausal
- Recreationally-active
- Weight stable for prior 6 months
You may not qualify if…
- Age outside of range (20 - 35 yrs)
- Pregnancy
- Irregular menstrual cycles (i.e., \~21 day or \~35 day cycle)
- Participation in previous research using [13C6]phenylalanine
- Participation in other ongoing research that interferes with this study (e.g., conflicting diet, activity interventions, etc.)
- Any hospitalization or surgery for a metabolic, cardiovascular, or neuromusculoskeletal complication within the past year
- Allergy or hypersensitivity to local anesthetics, latex, or adhesives (bandages, medical tape, etc.)
- Excess scarring after injury
- History of excess bleeding after cut
- Chronic or frequent dizziness/fainting, and arm or leg weakness/numbness
- Arthritis
- Tumors
- Mental Illness
- Hepatorenal, cardiovascular musculoskeletal, autoimmune, or neurological disease or disorder
- Predisposition to hypertrophic scarring or keloid formation
- Physical activity limitations
- Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation
- Consumption of thyroid, androgenic, or other medications known to affect endocrine function
- Consumption of medications known to affect protein metabolism (e.g., prescription-strength corticosteroids, non-steroidal anti-inflammatories, or acne medication)
- Unwillingness to comply with study procedures
- Weight unstable (variation >5% of bodyweight in last 6-12 months)
- Current or previous tobacco use with last 6 months
- Obesity (body mass index; BMI >>30 kg∙m\^-2)
- Score of less than 14 on the Godin-Shephard Leisure-Time Physical Activity Questionnaire
- Phenylketonuria
Where it is running
- Louise Freer Hall — Urbana, Illinois, United States
Full record on ClinicalTrials.gov
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